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Composition for treating cancer via liposomal aerosol formulation containing taxol

机译:通过含有紫杉醇的脂质体气雾剂制剂治疗癌症的组合物

摘要

The small particle liposome or lipid complex aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes or other lipid complexes. The liposomes and complexes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.
机译:本发明的小颗粒脂质体或脂质复合物气溶胶化合物和治疗方法涉及掺入脂质体或其他脂质复合物中的脂质或水溶性抗癌药。脂质体和复合物以水性分散体的形式从射流喷雾器施用于个体的呼吸道。可以使用各种抗癌药,包括20-S-喜树碱,9-硝基喜树碱,9-氨基喜树碱,10、11-亚甲基二氧喜树碱和紫杉酚或其衍生物。与肌肉内施用或口服施用相比,通过吸入施用这些药物提供了更快和更有效的抗癌药物吸收。

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