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Use of ligands specific to major histocompatibility complex-class I antigens for diagnosing endometriosis

机译:对主要组织相容性复合物I类抗原具有特异性的配体在诊断子宫内膜异位症中的用途

摘要

It is an object of the present invention to provide the clinicians with a new application for ligands specific to MHC-class I antigens, especially HLA-ABC antigens, this new application residing in the detection and diagnosis of endometriosis. It is also an object of the present invention to provide a method and a test kit for diagnosing endometriosis, preferably by immunohistochemistry, using a monoclonal anti- HLA-ABC antibody as a preferred ligand or diagnostic reagent. This new method is non-invasive and is more reliable as a screening test than the conventionally used laparoscopy. When the endometrium of a woman tests negatively with the claimed method, it prevents the use of laparoscopy which is an invasive method for detecting endometriosis. This method can be practised on a specimen obtained from the endometrium of a patient and does not require a specimen sampled directly from the endometriotic foci.
机译:发明内容本发明的目的是为临床医生提供针对MHC-I类抗原,特别是HLA-ABC抗原的特异性配体的新应用,该新应用驻留于子宫内膜异位症的检测和诊断。本发明的另一个目的是提供一种用于诊断子宫内膜异位的方法和试剂盒,其优选通过免疫组织化学,使用单克隆抗HLA-ABC抗体作为优选的配体或诊断试剂。这种新方法是非侵入性的,并且比常规腹腔镜检查更为可靠。当妇女的子宫内膜用要求保护的方法进行阴性测试时,它会阻止腹腔镜检查的使用,腹腔镜检查是一种用于检测子宫内膜异位的侵入性方法。该方法可以在从患者子宫内膜获得的标本上实施,并且不需要直接从子宫内膜异位灶采样的标本。

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