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USE OF DOPAMINE RECEPTOR ANTAGONISTS IN COMBINATION WITH PARTIAL DOPAMINE AGONIST TO PREVENT TOLERANCE IN TREATING NERVOUS DISORDERS RELATED TO DOPAMINE DYSFUNCTION
USE OF DOPAMINE RECEPTOR ANTAGONISTS IN COMBINATION WITH PARTIAL DOPAMINE AGONIST TO PREVENT TOLERANCE IN TREATING NERVOUS DISORDERS RELATED TO DOPAMINE DYSFUNCTION
Dopamine receptor antagonists are commonly prescribed for the treatment of schizophrenia and psychosis. While they are effective antipsychotics, they fail to treat other aspects of the disorder (e.g. negative symptoms, attention, and concentration) and have severe side effects, ranging from parkinsonism, acute motor side effects, akasthisia, dysphoria, and tardive dyskinesia. Dopamine agonist drug treatments are effective in treating both positive and negative symptoms without the common side effects. Unfortunately, dopamine agonists suffer from efficacy tolerance, the time limited effect on the order of 1-7 days. Thus, despite the partial effectiveness of current treatments, pressing need exists for new treatments. The combination drug therapy described herein meets this need. Specifically, the invention involves the use of small doses of dopamine receptor antagonists to reduce the intrinsic activity of a partial agonist, thereby reversing the agonist-induced tolerance commonly reported with agonist therapy alone.
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