首页>
外国专利>
Method for screening molecules that exert a neurotrophic effect through activation of neurotrophin receptors
Method for screening molecules that exert a neurotrophic effect through activation of neurotrophin receptors
展开▼
机译:筛选通过激活神经营养蛋白受体发挥神经营养作用的分子的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention is directed to a method for screening and identifying molecules that transactivate a neurotrophin receptor and mediate neuronal cell survival in the absence of neurotrophins which uses one or a combination of three different assays. The assays involve detecting the phosphorylation of a neurotrophin receptor, detecting the phosphorylation of phosphotidylinositol 3′-kinase or Akt enzyme, and assessing neuronal cell survival in the absence of neurotrophins.
展开▼