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HCP INHIBITOR AND COMPOUND HAVING HCP INHIBITING ACTIVITY

机译：HCP抑制剂和具有HCP抑制活性的化合物

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摘要

PROBLEM TO BE SOLVED: To provide a compound having activities of inhibiting a hematopoietic cell phosphatase(HCP) and excellent blood corpuscle-increasing activities, and further to provide a pharmaceutical composition containing the compound, an HCP inhibitor and a blood corpuscle-increasing agent.;SOLUTION: This pharmaceutical composition, especially the HCP inhibitor and the blood corpuscle-increasing agent, contains a compound represented by general formula [I] [wherein, R¹, R² and R³ are each a hydrogen atom, a halogen atom, a 1-6C alkoxy group, a 1-6C alxylamino group, a carboxy group or the like; R⁴ and R⁵ are each a hydrogen atom or a 1-6C alkyl group, or form a single bond by combining with each other; R⁶ is a hydrogen atom, a halogen atom, a carboxy group, a cyano group, a nitro group or an amino group; X is an oxygen atom, a single bond or -CONH-; and n is an integer of 0-4]. The composition is useful as the blood corpuscle-increasing agent after blood loss, a marrow-inhibiting and recovering agent after administration of an anticancer agent, an MDS therapeutic agent, a therapeutic agent for apastic anemia, a therapeutic agent for renal anemia, and the blood corpuscle-increasing agent at the time of transplantation of the marrow, the peripheral blood and the cord blood.;COPYRIGHT: (C)2002,JPO

机译：解决的问题：提供具有抑制造血细胞磷酸酶（HCP）的活性和优异的血红细胞增加活性的化合物，并且进一步提供包含该化合物，HCP抑制剂和血红细胞增加剂的药物组合物。 ;解决方案：该药物组合物，尤其是HCP抑制剂和血球增强剂，含有通式[I]表示的化合物[其中，R ^{1 ，R ^{2 和R ^{3 分别为氢原子，卤原子，1-6C烷氧基，1-6C烷基氨基，羧基等。 R ^{4 和R ^{5 分别为氢原子或1-6C烷基，或彼此结合形成单键。 R ^{6 是氢原子，卤素原子，羧基，氰基，硝基或氨基。 X是氧原子，单键或-CONH-; n是0-4的整数]。该组合物用作失血后的血红素增加剂，抗癌剂，MDS治疗剂，脂肪性贫血治疗剂，肾性贫血治疗剂给药后的骨髓抑制和恢复剂。骨髓，外周血和脐带血移植时的血红细胞增高剂。版权所有：（C）2002，日本特许厅}}}}}}

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公开/公告号JP2002275159A

专利类型
公开/公告日2002-09-25

原文格式PDF
申请/专利权人 JAPAN TOBACCO INC;
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申请/专利号JP20010076804
发明设计人 KAWASAKI HISASHI;OGASAWARA HIROYUKI;SHINODA KIYOTAKA;
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申请日2001-03-16
分类号C07D213/82;A61K31/437;A61K31/4439;A61K31/455;A61K31/496;A61K31/551;A61P7/06;A61P43/00;C07D401/12;A61P513/04;
国家 JP
入库时间 2022-08-22 00:58:50

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