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Matrix-type transdermal drug delivery systems that deliver steroid hormones at high rates and their use in hormone replacement therapy
Matrix-type transdermal drug delivery systems that deliver steroid hormones at high rates and their use in hormone replacement therapy
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机译：可高效率输送类固醇激素的基质型透皮给药系统及其在激素替代疗法中的用途
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摘要
The present invention refers to a transdermal patch for the release of Estradiol and at least one progestogen agent through the skin, comprising or consisting of an outer backing foil, a matrix and a protective liner wherein a) the Estradiol and the progestogen agent(s) are present in the matrix in an oversaturated solution, b) the matrix contains 1 to 5 wt% activated SiO2, and c) the matrix has a moisture content of less than 0.7 wt.-%. The patch can be used for hormonal replacement therapy.
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