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Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
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机译：通过抑制细胞周期进程，降低Bcl2并增加细胞凋亡来选择性治疗恶性细胞的化合物
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摘要
The invention provides compounds of the formula (I): ;wherein R1 is an amino or an alkyl group, optionally substituted with one or more groups selected from C1-C6 alkyl group; R2 is H or halogen; R3 is H, halogen, hydroxyl group, or alkyl group; R4 is H or halogen; and R5 is halogen, preferably chlorine; and salts and prodrugs thereof; and a method of using these compounds for the treatment of cancer.
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机译：本发明提供了式（I）的化合物：<化学ID =“ CHEM-US-00001”> <图像文件=“ US06277844-20010821-C00001.GIF” imgContent =“ undefined” imgFormat =“ GIF” /> ;其中R < Sub> 1 是氨基或烷基，可选地被一个或多个选自C 1- C 6 烷基的基团取代; R 2 是H或卤素; R 3 是H，卤素，羟基或烷基; R 4 是H或卤素; R 5 是卤素，优选氯;及其盐和前药;以及使用这些化合物治疗癌症的方法。
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