首页> 外国专利> Bicistronic DNA construct comprising X-myc transgene for use in production of transgenic animal model systems for human hepatocellular carcinoma and transgenic animal model systems so produced

Bicistronic DNA construct comprising X-myc transgene for use in production of transgenic animal model systems for human hepatocellular carcinoma and transgenic animal model systems so produced

机译：包含X-myc转基因的双顺反子DNA构建体，用于生产人肝细胞癌的转基因动物模型系统和由此生产的转基因动物模型系统

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摘要

The present invention relates to a bicistronic DNA construct comprising X-myc transgene. In particular, the present invention relates to a bicistronic X15-myc transgene capable of expressing truncated X protein and a full-length murine c-myc protein. More particularly, the present invention relates to a bicistronic DNA construct being an X15-myc transgene for use in the production of transgenic animal model systems for human hepatocellular carcinoma and transgenic animal model systems so produced. The invention is based partially on the discovery that in susceptible transgenic mice that carry a bicistronic X-myc transgene there is an accelerated formation of liver tumors involving all lobes.

机译：本发明涉及包含X-myc转基因的双顺反子DNA构建体。特别地，本发明涉及能够表达截短的X蛋白和全长鼠c-myc蛋白的双顺反子X15-myc转基因。更具体地，本发明涉及一种双顺反子DNA构建体，其是X15-myc转基因，用于生产用于人类肝细胞癌的转基因动物模型系统和由此产生的转基因动物模型系统。本发明部分地基于以下发现：在携带双顺反子X-myc转基因的易感转基因小鼠中，涉及所有叶的肝肿瘤的形成加速。

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公开/公告号US6274788B1

专利类型
公开/公告日2001-08-14

原文格式PDF
申请/专利权人 INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY;NATIONAL INSTITUTE OF IMMUNOLOGY;
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申请/专利号US19990243282
发明设计人 RAJESH ANAND;MAHAVIR SINGH;SATISH TOTEY;VJAY KUMAR;
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申请日1999-02-02
分类号A01K670/70;G01N330/00;C07H210/40;
国家 US
入库时间 2022-08-22 01:03:37

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