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Bacteriocins produced by ruminal bacteria

机译:瘤胃细菌产生的细菌素

摘要

Proteinaceous antibiotics produced by ruminal bacteria are provided. The diverse group of ruminal bacteria known as Butyrivibrio spp. is a preferred source of such proteinaceous antibiotics. The proteinaceous antibiotics are generally resistant to gastric proteases, exhibit a high level of hydrophobicity, are effective to inhibit growth of target organisms under anaerobic conditions, are ineffective in aerobic conditions, and have a molecular weight of less than about 5 kDa. Also provided are methods for identifying ruminal bacteria which produce such proteinaceous antibiotics, and methods for producing the proteinaceous antibiotics.
机译:提供了由瘤胃细菌产生的蛋白质抗生素。不同种类的瘤胃细菌,称为Butyrivibrio spp。这种蛋白质抗生素的优选来源。蛋白质抗生素通常对胃蛋白酶有抗性,表现出高水平的疏水性,在厌氧条件下有效抑制靶生物的生长,在需氧条件下无效,并且分子量小于约5kDa。还提供了鉴定产生这种蛋白质抗生素的瘤胃细菌的方法,以及产生蛋白质抗生素的方法。

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