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Methods and assay kits for detecting altered mononuclear cell phenotype related to a pro-tumor immune response

机译:用于检测与促肿瘤免疫反应有关的改变的单核细胞表型的方法和检测试剂盒

摘要

A method for screening for a pro-tumor immune response according to the present invention, the method comprises: contacting a clinical sample with one or more detector molecules for detecting, and then determining the amount of, mononuclear cell phenotype in the sample; and (b) comparing the amount of mononuclear cell phenotype determined in the sample to a reference value for the mononuclear cell phenotype; wherein a significant difference in the amount of mononuclear cell phenotype determined as compared to the reference value may be an indicator of the presence of a pro-tumor immune response. Also provided are assay kits for determining an amount of mononuclear cell phenotype in performing the methods according to the present invention.
机译:根据本发明的用于筛选促肿瘤免疫应答的方法,该方法包括:使临床样品与一个或多个检测分子接触,以检测样品中的单核细胞表型,然后确定其数量;以及(b)将样品中测定的单核细胞表型的量与单核细胞表型的参考值进行比较;其中确定的单核细胞表型数量与参考值相比的显着差异可以指示存在肿瘤前免疫应答。还提供了用于在执行根据本发明的方法中确定单核细胞表型量的测定试剂盒。

著录项

  • 公开/公告号US6251616B1

    专利类型

  • 公开/公告日2001-06-26

    原文格式PDF

  • 申请/专利权人 BIOCRYSTAL LTD.;

    申请/专利号US19990435289

  • 发明设计人 EMILIO BARBERA-GUILLEM;M. BUD NELSON;

    申请日1999-11-05

  • 分类号G01N335/74;G01N335/30;G01N335/55;G01N335/67;

  • 国家 US

  • 入库时间 2022-08-22 01:04:01

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