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Methods for the solid phase synthesis of combinatorial libraries of benzimidazoles benzoxazoles benzothiazoles and derivatives thereof

机译:苯并咪唑苯并恶唑苯并噻唑及其衍生物组合库的固相合成方法

摘要

The present invention provides an efficient and versatile method for the synthesis and screening of combinatorial libraries of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof. In order to expedite the synthesis of large arrays of compounds possessing these core structures, a general methodology for solid phase synthesis of these derivatives is provided. Arrays of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antiviral, antimicrobial, anticoagulant, and antiulcer activity, or use in the treatment of inflammation, hypertension, cancer, and other conditions can be prepared by this method.
机译:本发明提供了用于合成和筛选苯并咪唑,苯并恶唑,苯并噻唑及其衍生物的组合文库的有效且通用的方法。为了加速合成具有这些核心结构的大量化合物,提供了用于这些衍生物的固相合成的通用方法。可用作肽模拟物并用于鉴定具有抗真菌,抗病毒,抗微生物,抗凝血和抗溃疡活性的药物或用于治疗炎症,高血压,癌症和其他疾病的苯并咪唑,苯并恶唑,苯并噻唑及其衍生物的阵列用这种方法准备的。

著录项

  • 公开/公告号US6251689B1

    专利类型

  • 公开/公告日2001-06-26

    原文格式PDF

  • 申请/专利权人 TELIK INC.;

    申请/专利号US19990313568

  • 发明设计人 YUKIHARU MATSUMOTO;EDGARDO LABORDE;

    申请日1999-05-14

  • 分类号G01N335/43;

  • 国家 US

  • 入库时间 2022-08-22 01:04:01

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