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Methods of stimulating mitogenesis in glial cells using glial mitogenic factors

机译:利用神经胶质有丝分裂因子刺激神经胶质细胞有丝分裂的方法

摘要

The invention features methods for stimulating glial cell mitogenesis by contacting the glial cells with p185erbB2 ligand polypeptides, including glial growth factor (GGF), a GGF splice variant comprised of segments E, B, A, C, and C/D or C/D, a 35 kD polypeptide factor isolated from rat I-EJ transformed fibroblast cells, 75 kD polypeptide factor isolated from the LKBR-3 human breast cells, 44 kD polypeptide factor isolated from the rat I-EJ transformed fibroblast cells, 45 kD polypeptide factor isolated from MDA-MB 231 human breast cells, 7-14 kD polypeptide factor isolated from the ATL-2 human T-cells, 25 kD polypeptide factor isolated from activated mouse peritoneal macrophages, and 25 kD polypeptide factor isolated from bovine kidney.
机译:本发明的特征在于通过使神经胶质细胞与p185 erbB2 配体多肽接触来刺激神经胶质细胞有丝分裂的方法,所述多肽包括神经胶质生长因子(GGF),GGF剪接变体,由片段E,B,A,C,和C / D或C / D,从大鼠I-EJ转化的成纤维细胞分离的35 kD多肽因子,从LKBR-3人乳腺细胞分离的75 kD多肽因子,从大鼠I-EJ转化的分离的44 kD多肽因子成纤维细胞,从MDA-MB 231人乳腺细胞分离的45 kD多肽因子,从ATL-2人T细胞分离的7-14 kD多肽因子,从活化的小鼠腹膜巨噬细胞分离的25 kD多肽因子和25 kD多肽因子从牛肾脏分离。

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