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Cultures of trisomy 21 cytotrophoblasts for assessing risk of trisomy 21, without the need for fetal karyotyping comprises for identifying markers
Cultures of trisomy 21 cytotrophoblasts for assessing risk of trisomy 21, without the need for fetal karyotyping comprises for identifying markers
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机译：21三体细胞滋养细胞培养物可用于评估21三体风险，而无需进行胎儿核型分析，可用于鉴定标记
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摘要
Culturing cytotrophoblasts, (A), that are trisomic for human chromosome 21, or for a region of this that contains at least the gene encoding copper-zinc superoxide dismutase, after 3 days of culture, (A) express at least one peptide hormone (I) at below the mean level for normal placental cytotrophoblasts at the same stage of gestation and cultured under the same conditions, is new. Where (I) are human placental lactogen (hPL), human chorionic gonadotropin (hCG) alpha or beta human placental growth hormone (PGH) and/or leptin. Independent claims are also included for the following: (1) differential expression libraries of nucleic acid prepared from at least one culture of (A); and (2) determining the risk of trisomy 21 in a fetus.
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