首页> 外国专利> DEFENSINE DEFENSINE POLYPEPTIDE DEF-X, GENOMIC DNA AND CDNA, COMPOSITION CONTAINING THEM AND APPLICATIONS TO DIAGNOSIS AND THERAPEUTIC TREATMENT

DEFENSINE DEFENSINE POLYPEPTIDE DEF-X, GENOMIC DNA AND CDNA, COMPOSITION CONTAINING THEM AND APPLICATIONS TO DIAGNOSIS AND THERAPEUTIC TREATMENT

机译：防御素防御素多肽DEF-X，基因组DNA和CDNA，包含它们的成分及其在诊断和治疗中的应用

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摘要

The present invention relates to a novel human polypeptide defensin Def-X, genomic DNA and cDNA encoding Def-X, vectors containing Def-X encoding polynucleotides, and cells transformed with these vectors. The invention also provides for the use of Def-X polypeptides as an antibiotic, a cytotoxic, repair, and endocrine regulatory agent, and as pesticide. Def-X can also be used as agent, a cosmetic or pharmaceutical compositions for the treatment of microbial infections, in particular bacterial, fungal, and viral infections, parasitic infections, cancer, inflammation, and immune deficiencies. The invention provides diagnostic methods and kits for the determination of a microbial or parasitic infection and/or inflammation; also provided are methods of screening for predisposition to immune deficiencies or cancer.

机译：本发明涉及新型人多肽防御素Def-X，编码Def-X的基因组DNA和cDNA，含有Def-X编码多核苷酸的载体，以及用这些载体转化的细胞。本发明还提供了Def-X多肽作为抗生素，细胞毒性，修复和内分泌调节剂以及作为农药的用途。 Def-X还可以用作试剂，化妆品或药物组合物，用于治疗微生物感染，特别是细菌，真菌和病毒感染，寄生虫感染，癌症，炎症和免疫缺陷。本发明提供了用于确定微生物或寄生虫感染和/或炎症的诊断方法和试剂盒;还提供了对免疫缺陷或癌症易感性的筛选方法。

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公开/公告号FR2767832B1

专利类型
公开/公告日2001-08-10

原文格式PDF
申请/专利权人 GENSET;
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申请/专利号FR19970010823
发明设计人 LYDIE BOUGUELERET;ILYA CHUMAKOV;
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申请日1997-08-29
分类号C07K14/47;C07K16/18;C12N15/12;C12N15/74;C12N15/85;C12P21/02;C07H21/02;A61K48/00;A61K38/17;A61K7/00;C12Q1/68;G01N33/68;
国家 FR
入库时间 2022-08-22 01:08:05

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