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Composition for treating allergic and/or vasomotor rhinitis or allergic conjunctivitis by topical or oral administration, contains synergistic combination of non-sedating antihistamine and leukotriene antagonist
Composition for treating allergic and/or vasomotor rhinitis or allergic conjunctivitis by topical or oral administration, contains synergistic combination of non-sedating antihistamine and leukotriene antagonist
Pharmaceutical composition comprises (separately or in combination): (A) a non-sedating antihistamine (or its salt), other than compounds of the loratadine type; (B) a leukotriene antagonist (or its salt) comprising (B1) leukotriene D 4 antagonists, (B2) 5-lipoxygenase inhibitors or (B3) FLAP (5-lipoxygenase activating protein) antagonists; and (C) conventional carriers and/or extenders or auxiliaries. Independent claims are included for the following: (i) the use of a combination of (A)-(C) for the preparation of a medicament for use as above; (ii) a medicament comprising (A)-(C), for use as above; and (iii) the preparation of the medicaments, by mixing and formulating the appropriate components. - ACTIVITY : Antiallergic; antiinflammatory; ophthalmological. In tests for inhibition of ovalbumin-induced nasal mucosal permeability in sensitized rats, the degree of inhibition was 11% using azelastine alone at 0.01 mg/kg i.p., 7% using montelukast alone at 0.1 mg/kg i.p. and 40% using a combination of azelastine at 0.01 mg/kg i.p. and montelukast at 0.1 mg/kg i.p. - MECHANISM OF ACTION : Antihistamine; leukotriene D 4 antagonist; 5-lipoxygenase inhibitor; FLAP (5-lipoxygenase activating protein) antagonist.
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机译：药物组合物包含（单独或组合）：（A）除氯雷他定类型的化合物以外的非镇静性抗组胺药（或其盐）; （B）白三烯拮抗剂（或其盐），其包含（B1）白三烯D 4拮抗剂，（B2）5-脂氧合酶抑制剂或（B3）FLAP（5-脂氧合酶活化蛋白）拮抗剂; （C）常规载体和/或增量剂或助剂。下列各项包括独立权利要求：（i）（A）-（C）的组合在制备用于上述用途的药物中的用途; （ii）用于上述用途的包含（A）-（C）的药物; （iii）通过混合和配制适当的成分来制备药物。 -活动：抗过敏;消炎（药;眼科的在抑制卵白蛋白引起的敏化大鼠鼻粘膜通透性的试验中，单独使用氮卓斯汀（0.01 mg / kg i.p.）的抑制率为11％，单独使用孟鲁司特以0.1 mg / kg i.p的抑制率为7％。并以0.01 mg / kg i.p.的氮卓斯汀组合使用40％和孟鲁司特以0.1 mg / kg的腹腔注射-作用机理：抗组胺药;白三烯D 4拮抗剂; 5-脂氧合酶抑制剂; FLAP（5-脂氧合酶激活蛋白）拮抗剂。
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