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Plaster-form transdermal therapeutic system containing zaleplon, especially for use as hypnotic agent, providing safe and controlled drug delivery
Plaster-form transdermal therapeutic system containing zaleplon, especially for use as hypnotic agent, providing safe and controlled drug delivery
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机译：含有扎来普隆的膏药形式的透皮治疗系统，特别是用作催眠药，提供安全可控的药物输送
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摘要
A pharmaceutical preparation containing zaleplon (I) consists of a transdermal therapeutic system (TTS) in plaster form, comprising a backing layer, a (I)-containing pressure sensitive reservoir is bonded to the backing layer and a protective layer to be removed before use. An independent claim is included for the preparation of the TTS, by: (1) dissolving (I) and a skin penetration promoter in a solubilizer, such that the dissolved (I) concentration reaches saturation; (2) dispersing the solution under stirring in a pressure-sensitive adhesive solution; (3) coating the dispersion on a carrier film; (4) drying; (5) laminating with another film; (6) stamping out a TTS of the required area; and (7) packaging.
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