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Vector constructs for gene therapy mediated radioiodine therapy of undifferentiated and medullary thyroid carcinomas as well as non-thyroid tumors and their metastases
Vector constructs for gene therapy mediated radioiodine therapy of undifferentiated and medullary thyroid carcinomas as well as non-thyroid tumors and their metastases
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机译:用于基因疗法介导的放射性碘治疗未分化和甲状腺髓样癌以及非甲状腺肿瘤及其转移的载体构建体
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摘要
The invention relates to vector constructs, comprising vector DNA which includes regulatory sequences, the NIS gene coding for the sodium/iodide symporter, the TPO gene coding for thyroidal peroxidase and use thereof for production of a medicament/diagnostic for treatment/diagnosis of tumour disease states, whereby treatment occurs before or concurrent with a radionuclide therapy, in particular, with iodine-131, or astatine-211. The invention further relates to use of two or several vector constructs for production of a medicament/diagnostic for treatment/diagnosis of tumour disease states.
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