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Human P2YLi gene coding for a putative G protein coupled receptor used to develop new drugs and technologies and to evaluate existing drugs
Human P2YLi gene coding for a putative G protein coupled receptor used to develop new drugs and technologies and to evaluate existing drugs
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机译：人类P2YLi基因编码一个假定的G蛋白偶联受体，用于开发新药物和新技术以及评估现有药物
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摘要
The P2YLi gene, having a 3180 base pair sequence, fully defined in the specification, including 5'- and 3'-untranslated regions, and which overlaps with the gene for acrosomal protein SP32, is new. Independent claims are also included for the following: (1) transcription factors, RNA polymerases, drugs and chemicals that positively or negatively modulate expression of the P2YLi gene; (2) mRNA transcripts of the P2YLi gene, including splice variants and isoforms; (3) cDNA derived from the mRNA or from the intronless P2YLi gene; (4) a protein derived or produced from the mRNA, gene or cDNA; (5) antibodies and antisera raised against one or more epitopes of the proteins or against the protein as a whole; (6) expression systems that express the protein of (4); (7) ligand binding studies and screening assays on native or recombinant receptors or cells or cell membranes containing the protein of (4); (8) transgenic animals and knockout animals which express the protein of (4) at an altered density or not at all; (9) gene therapy methods that concern the protein of (4) or its gene or its mRNA (cDNA) and their development and use; (10) sense and antisense oligonucleotides derived from the P2YLi gene and their use; and (11) diagnosis and treatment of diseases that are directly or indirectly associated with the protein of (4).
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