首页> 外国专利> Composition for promoting hematopoietic stem cell and platelet progenitor cell proliferation containing antler extract

Composition for promoting hematopoietic stem cell and platelet progenitor cell proliferation containing antler extract

机译:包含鹿茸提取物的促进造血干细胞和血小板祖细胞增殖的组合物

摘要

The present invention provides a composition for promoting hematopoietic stem and platelet progenitor cell (megakaryocyte) proliferation, and a chloroform extract of such antler, containing a specific extract of antler, particularly chloroform extract of antler, and fractions separated and purified therefrom. A method for extracting, separating and purifying fractions. In addition, the present invention confirms that the compounds represented by the following formula (1) as the active ingredient showing the hematopoietic stem cell and platelet progenitor proliferation promoting activity in the extract of the antler, the synthesis method thereof and hematopoietic containing them as an active ingredient Provided are compositions for promoting proliferating parental and platelet progenitor cells, and also novel compounds in compounds of formula (I).;[Formula 1];Wherein R 1 / R 2 is 9-octadecenoyl / hexadecanoyl, hexadecanoyl / 9-octadecenoyl, hexadecanoyl / 9,12-octadecadienoyl, hexadecanoyl / 9, 12,15-octadecaterienoyl or hexadecanoyl / 5,8,11,14-eicotetraenoyl, and R 3 represents acetyl.
机译:本发明提供了用于促进造血干细胞和血小板祖细胞(巨核细胞)增殖的组合物,以及这种鹿角的氯仿提取物,其包含鹿角的特定提取物,特别是鹿角的氯仿提取物,以及从中分离和纯化的级分。一种提取,分离和纯化级分的方法。另外,本发明证实了由下式(1)表示的化合物作为活性成分,其在鹿茸提取物,其合成方法和包含它们的造血细胞中显示出促进造血干细胞和血小板祖细胞增殖的活性。活性成分提供用于促进增殖的亲代和血小板祖细胞的组合物,以及式(I)化合物中的新化合物。[式1];其中R 1 / R 2 是9-十八碳酰基/十六碳酰基,十六碳酰基/ 9-十八碳酰基,十六碳酰基/ 9,12-十八碳十二碳酰基,十六碳酰基/ 9,12,15-十八碳十六碳酰基或十六碳酰基/ 5,8,11,14-二十碳四烯酰基和R 3 代表乙酰基。

著录项

  • 公开/公告号KR100283010B1

    专利类型

  • 公开/公告日2001-04-02

    原文格式PDF

  • 申请/专利权人

    申请/专利号KR19980030819

  • 申请日1998-07-30

  • 分类号A61K35/36;A61K35/14;

  • 国家 KR

  • 入库时间 2022-08-22 01:12:32

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