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-1 - - A New thermostable D-stereospecific dipeptidase from Brevibacillus borstelensis BCS-1 and its use as a biocatalyst for the synthesis of peptides containing D-amino acids
-1 - - A New thermostable D-stereospecific dipeptidase from Brevibacillus borstelensis BCS-1 and its use as a biocatalyst for the synthesis of peptides containing D-amino acids
PURPOSE: Provided are a novel D-stereo specific dipeptidase derived from thermophile, Brevibacillus borstelensis bcs-1 (KCTC0673BP) and a synthesis method of D-amino acid-containing peptide using the same as a catalyst. CONSTITUTION: D-amino acid-containing peptide useful in the field of industry can be synthesized economically and environmentally friendly by the steps of: developing a detection method of D-peptide derivative hydrolase; selecting thermophile, Brevibacillus borstelensis bcs-1 (KCTC0673BP); obtaining a novel D-stereo specific dipeptidase derived from the Brevibacillus borstelensis bcs-1 and showing thermostability particularly at 55 deg.C, high pH stability especially in the range of pH7-10 and substrate stability, further its gene, a recombinant vector and transformants; synthesizing D-amino acid-containing peptide, peptide sweetener or L,D-structure of dipeptide by using them.
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