首页> 外国专利> CHIMERIC GENE ENABLING EXPRESSION OF THE GENE OR CDNA OF TYPE I INSULIN-LIKE GROWTH FACTOR (IGF-I) IN THE PANCREAS AND UTILIZATION THEREOF IN GENIC THERAPY OF DIABETES MELLITUS

CHIMERIC GENE ENABLING EXPRESSION OF THE GENE OR CDNA OF TYPE I INSULIN-LIKE GROWTH FACTOR (IGF-I) IN THE PANCREAS AND UTILIZATION THEREOF IN GENIC THERAPY OF DIABETES MELLITUS

机译:嵌合基因使胰腺中I型胰岛素样生长因子(IGF-I)的基因或CDNA的表达及其在糖尿病的全身治疗中的利用

摘要

The invention relates to a chimeric gene using the gene or cDNA of type I insulin-like growth factor (IGF-I) directed by a promoter or promoter fusion enabling regulated expression of IGF-I in the pancreas. The invention also relates to an expression vector enabling the expression of IGF-I in the pancreas. The invention further relates to a pancreatic cell expressing said chimeric gene. The invention additionally relates to the utilization of said chimeric gene or said expression vector in the development of therapeutic application for diabetes mellitus.
机译:本发明涉及一种嵌合基因,其使用由启动子或启动子融合物引导的I型胰岛素样生长因子(IGF-1)的基因或cDNA,从而能够调节胰腺中IGF-1的表达。本发明还涉及能够在胰腺中表达IGF-1的表达载体。本发明进一步涉及表达所述嵌合基因的胰腺细胞。本发明还涉及所述嵌合基因或所述表达载体在糖尿病治疗应用开发中的用途。

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