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Cephaibols, novel antiparasitics from acremonium tubakii, method for the production and the utilization thereof
Cephaibols, novel antiparasitics from acremonium tubakii, method for the production and the utilization thereof
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机译：Cephaibols，一种来自塔布孔菌的新型抗寄生虫药，其生产和利用方法
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摘要
The invention relates to compounds of the formula I ?in-line-formulae description="In-line Formulae" end="lead"?AcPhe-Aib-Aib-Aib-x-w-Leu-y-Aib-Hyp-Gln-z-Hyp-Aib-Pro-R (I)?in-line-formulae description="In-line Formulae" end="tail"? in which R is Phe-ol or Phe-al and w, x, y, and z have the following meanings: a) w is Gly or Ala; x is Aib and y and z are Iva; b) w is Gly; x, y and z are Iva; c) w is Gly; x and z are Aib and y is Iva; d) w is Gly; x, y and z are Aib; or e) w is Gly; x and y are Aib and z is Iva; or of the formula II ?in-line-formulae description="In-line Formulae" end="lead"?AcPhe-Iva-Gln-Aib-lle-Thr-Aib-Leu-Aib-x-Gln-Aib-Hyp-Aib-Pro-Phe-Ser, (II)?in-line-formulae description="In-line Formulae" end="tail"? wherein x is Hyp or Pro, which are synthesized by Acremonium tubakii FH 1685 DSM 12774 during fermentation and released into the culture medium, a process for the isolation of the cephaibols from the culture medium, and their purification, and the use of the cephaibols as pharmacologically active compounds, in particular for the control of parasites.
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