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Chimeric proteins for detection and quantitation of dna mutations, dna sequence variations, dna damage and dna mismatches
Chimeric proteins for detection and quantitation of dna mutations, dna sequence variations, dna damage and dna mismatches
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机译：用于检测和定量dna突变，dna序列变异，dna损伤和dna错配的嵌合蛋白
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摘要
Chimeric proteins having both DNA mutation binding activity and nuclease activity are synthesized by recombinant technology. The proteins are of the general formula A-L-B and B-L-A where A is a peptide having DNA mutation binding activity, L is a linker and B is a peptide having nuclease activity. The chimeric proteins are useful for detection and identification of DNA sequence variations including DNA mutations (including DNA damage and mismatches) by binding to the DNA mutation and cutting the DNA once the DNA mutation is detected.
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