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Crystal structure of acyl carrier protein synthase and acyl carrier protein synthase complex

机译:酰基载体蛋白合酶和酰基载体蛋白合酶复合物的晶体结构

摘要

This invention is directed to Acyl Carrier Protein Synthase (ACPS) crystals and crystals of Acyl Carrier Protein Synthase-Coenzyme A (ACPS-CoA) complex, and to the use of these crystals to determine the three dimensional structure of ACPS. This invention is further directed to the use of rational drug design methods to identify agents that may interact with active sites of ACPS and ACPS-CoA complex, and to the testing of these agents to identify agents that may inhibit ACPS and/or ACPS-CoA complex activity.
机译:本发明涉及酰基载体蛋白合酶(ACPS)晶体和酰基载体蛋白合酶-辅酶A(ACPS-CoA)复合物的晶体,并涉及这些晶体在确定ACPS的三维结构中的用途。本发明进一步涉及使用合理的药物设计方法来鉴定可与ACPS和ACPS-CoA复合物的活性位点相互作用的药物,并且涉及对这些药物的测试以鉴定可抑制ACPS和/或ACPS-CoA的药物。复杂的活动。

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