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Bifunctional molecules having modulated pharmacokinetic properties and therapies based thereon

机译：具有调节的药代动力学性质的双功能分子和基于其的疗法

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摘要

Bifunctional molecules and methods for their use are provided. The subject bifunctional molecules are conjugates of a drug moiety and a pharmacokinetic modulating moiety, where these two moieties are optionally joined by a linking group. The bifunctional molecules are further characterized in that they exhibit at least one modulated pharmacokinetic property upon administration to a host as compared to a free drug control. The subject bifunctional molecules find use in a variety of therapeutic applications.

机译：提供了双功能分子及其使用方法。所述双功能分子是药物部分和药代动力学调节部分的缀合物，其中这两个部分任选地通过连接基团连接。双功能分子的特征还在于，与游离药物对照相比，它们在施用于宿主后表现出至少一种调节的药代动力学性质。本发明的双功能分子可用于多种治疗应用中。

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公开/公告号AU2043901A

专利类型
公开/公告日2001-05-30

原文格式PDF
申请/专利权人 THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;
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申请/专利号AU20010020439
发明设计人 THOMAS WANDLESS;ROGER BRIESEWITZ;GERALD R CRABTREE;
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申请日2000-11-17
分类号A01N61/00;A61K38/00;A61K38/43;C12N11/00;C12N11/02;C07K1/00;C07K17/00;C07K17/02;C07K17/06;
国家 AU
入库时间 2022-08-22 01:21:01

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