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VACCINES AGAINST CONFORMATION-DEPENDENT ANTIGENS AND AGAINST ANTIGENS THAT ARE NOT OR ARE NOT ONLY PROTEINS OR PEPTIDES
VACCINES AGAINST CONFORMATION-DEPENDENT ANTIGENS AND AGAINST ANTIGENS THAT ARE NOT OR ARE NOT ONLY PROTEINS OR PEPTIDES
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机译：针对不是或不是唯一的蛋白质或肽的构象依赖性抗原和抗原的疫苗
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摘要
The invention relates to a method that makes it possible to use the highlyeffective technology of vaccination with deoxyribonucleic acid (DNA) not onlyon sequence epitopes of proteins or peptides, but also on conformationepitopes. The method also permits the use of DNA vaccination for antigens thatare not or are only partially proteins or peptides. The preferred inventivevaccine contains a desoxyribonucleic acid (DNA) as its principal component.This desoxyribonucleic acid codes for a peptide sequence which represents theimmunological imitation (mimicry) of a conformation-dependent antigenincluding protein conformation epitopes or of an antigen that is not or isonly partially a protein or peptide. The mimicry peptide, which is also or canalso be part of the inventive vaccine, is either an antiidiotypic antibody, anantibody fragment, a peptide derived therefrom or a specifically bindingpeptide obtained by selection from a peptide gene bank. The invention can beused in medical and veterinary medical immunology, including in the adjuvanttherapy of tumor diseases.
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