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Tablet for immediate and sustained drug release, having immediate release layer and sustained release layer containing polymer matrix

机译:用于立即和持续释放药物的片剂,具有含有聚合物基质的立即释放层和持续释放层

摘要

A multi-layer tablet for the instant and prolonged release of active substances comprises at least two layers where the first outer layer comprises a mixture of excipients and an active substance, allowing for the immediate release of the active substance within the first layer, and a second layer, arranged in contact with the first layer. The second layer comprises a nonbiodegradable inert porous polymeric matrix in which an active substance is dispersed, allowing for the prolonged release of the active substance within the second layer.
机译:用于立即和长时间释放活性物质的多层片剂包括至少两层,其中第一外层包含赋形剂和活性物质的混合物,以允许活性物质在第一层内立即释放,以及第二层布置成与第一层接触。第二层包括不可生物降解的惰性多孔聚合物基质,其中活性物质分散在其中,从而允许活性物质在第二层内延长释放。

著录项

  • 公开/公告号ID26313A

    专利类型

  • 公开/公告日2000-12-14

    原文格式PDF

  • 申请/专利权人 MERCK PATENT GMBH;

    申请/专利号ID20000001144

  • 发明设计人 OLIVIER SASLAWSKI;LAURENCE ORLANDO;

    申请日1998-12-11

  • 分类号A61K9/20;

  • 国家 ID

  • 入库时间 2022-08-22 01:23:42

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