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GENETIC THERAPY OF DISEASES INDUCED BY THE IMMUNE SYSTEM WITH THE ASSISTANCE OF A REGULATORY SUBSTANCE OF THE CELL SPECIFIC CELL CYCLE
GENETIC THERAPY OF DISEASES INDUCED BY THE IMMUNE SYSTEM WITH THE ASSISTANCE OF A REGULATORY SUBSTANCE OF THE CELL SPECIFIC CELL CYCLE
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机译:免疫系统诱发的疾病的基因治疗,并需要细胞特异性细胞周期的调节性物质的协助
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摘要
A DNA sequence is described for the gene therapy of diseases associated with the immune system. In its essential elements, the DNA sequence is composed of an activator sequence, a promoter module and a gene for the active substance. The activator sequence is activated in a cell-specific or virus-specific manner and this activation is regulated by the promoter module in a cell cycle-specific manner. The choice of activator sequence and active substance depends on the indication area. The DNA sequence is inserted into a viral or non-viral vector which is supplemented by a ligand having affinity for the target cell. Depending on the choice of activator sequence and active substance, the following can be treated by administering the DNA sequence: defective formation of blood cells autoimmune diseases and allergies and, in addition, rejection reactions against transplanted organs chronic arthritis viral and parasitic infections and, in addition, prophylaxis of viral, bacterial and parasitic infections, and leukaemias.
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