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Library of substances containing imidazo - 5 - il - biciclicas amines and / or imidazo - 3 - il - biciclicas amines, Process for the preparation of this Library of substances,This Library and use of substances for the preparation of medicines.
Library of substances containing imidazo - 5 - il - biciclicas amines and / or imidazo - 3 - il - biciclicas amines, Process for the preparation of this Library of substances,This Library and use of substances for the preparation of medicines.
Refers to compounds containing imidazo - 5 - ilamina biciclicas and / or imidazo - 3 - il - biciclicas amines of formula I, II; r1 is C (CH3) 3 (CH2) 6, phenyl, cycloalkyl c4-c8, ch2ch2r, offers,3 - tetrametilbutilo, ch2ra, among others; R is 4 - morpholino; ra is H, alkyl, phenyl - C1 to C8, coor `; R is alkyl C1 C8, PO (OR) 2; R is alkyl (c1-c4, IF rxryrz), RX, Ry, RZ are alkyl C1 C8PHENYL, R2 is H, Corb RB is H, alkyl, cycloalkyl C1 - C3 - C8 C8, ch2ch2co (or 'C1'); R is alkyl, phenyl - C8, Adamantyl, among others; R3 is C1 C8 alkyl, cycloalkyl C3, C8, phenylAmong others, CR7 is X, N, S; when X is s, and CR8, N; W is n; Z is few, CR10, N; W and Z n are not at the same time, R4, R5, R6, R7, R8, R9, R10 is H, alkyl C1 C8, f, CL, BR, CN, CF3,Among others; it also relates to the production of compounds which comprises reacting amidines III, IV, aldehyde Cho R1 - R3; isonitriles (+) and (-) in dichloromethane and perchloric acid,Eventually r2hal is reacted with isocyanate or a Lame; Preferred compounds are Tertiary Butyl - (Cyclohexyl - imidazo [1,2-a] pyridin-3-yl) - Amine - (2-methyl Cyclohexyl - imidazo [1,2 -] pyridin-3-yl) Amine, among others. The compounds may be useful for the treatment of Pain
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