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首页> 外国专利> 2-aminopyrroline compounds characterised by presence of cyclopropyl group (e.g. N-(2-cyclopropylphenyl)-3,4-dihydro-2H-pyrrol-5-amine, N-(dicyclopropylmethyl)-3,4-dihydro-2H-pyrrol-5-amine or N-(2-cyclopropylphenyl)-2-methyl-3,4-dihydro-2H-pyrrol-5-amine for treating cardiovascular related diseases

2-aminopyrroline compounds characterised by presence of cyclopropyl group (e.g. N-(2-cyclopropylphenyl)-3,4-dihydro-2H-pyrrol-5-amine, N-(dicyclopropylmethyl)-3,4-dihydro-2H-pyrrol-5-amine or N-(2-cyclopropylphenyl)-2-methyl-3,4-dihydro-2H-pyrrol-5-amine for treating cardiovascular related diseases

机译：2-氨基吡咯啉化合物，其特征在于存在环丙基（例如N-（2-环丙基苯基）-3,4-二氢-2H-吡咯-5-胺，N-（二环丙基甲基）-3,4-二氢-2H-吡咯- 5-胺或N-（2-环丙基苯基）-2-甲基-3,4-二氢-2H-吡咯-5-胺用于治疗心血管相关疾病

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摘要

Compounds having 2-aminopyrroline structure as shown; characterised by the presence of a cyclopropyl group associated with the aminopyrroline ring useful in the treatment of cardiovascular diseases, especially arterial hypertension, arrhythmia and associated disorders. Wherein; n is 1 or 2; X represents an alkylene, alkenylene or alkynylene group, or an optionally substituted arylene group, or an optionally substituted heteroarylene group; R10 represents a hydrogen atom or a linear or branched C1-6alkyl group and R11 and R12 together form a bond, or alternatively R12 represents a hydrogen atom or a linear or branched C1-6alkyl group and R10 and R11 together form a bond; R2, R3 and R4 each independently of the others represents a hydrogen atom, a linear or branched C1-6alkyl group, a linear or branched C1-6hydroxyalkyl group, a linear or branched C1-6alkoxy group, a linear or branched C1-6alkoxycarbonyl group, an optionally substituted aryl group, an optionally substituted arylalkyl group in which the alkyl moiety is linear or branched and has from 1 to 6 carbon atoms, or an optionally substituted aryloxyalkyl group in which the alkyl moiety is linear or branched and has from 1 to 6 carbon atoms, or alternatively two of R2, R3 and R4, with the carbon atoms carrying them, form a C5-7cycloalkyl group.
机译：如图所示，具有2-氨基吡咯啉结构的化合物;其特征在于存在与氨基吡咯啉环相关的环丙基，该环丙基可用于治疗心血管疾病，特别是动脉高血压，心律不齐和相关疾病。其中n为1或2; X代表亚烷基，亚烯基或亚炔基，或任选取代的亚芳基，或任选取代的杂亚芳基; R 10表示氢原子或直链或支链的C 1-6烷基，R 11和R 12一起形成键，或者R 12表示氢原子或直链或支链的C 1-6烷基，并且R 10和R 11一起形成键。 R 2，R 3和R 4彼此独立地表示氢原子，直链或支链的C 1-6烷基，直链或支链的C 1-6羟烷基，直链或支链的C 1-6烷氧基，直链或支链的C 1-6烷氧基羰基，任选取代的芳基，其中烷基部分为直链或支链且具有1至6个碳原子的任选取代的芳基烷基，或其中烷基部分为直链或支链且具有1至1至1的碳原子的任选取代的芳氧基烷基6个碳原子，或R 2，R 3和R 4中的两个，碳原子携带它们，形成C 5-7环烷​​基。

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