首页> 外国专利> 6-Amino-9-benzyl-8-hydroxy-purine derivatives and interferon inducers, antiviral agents, anticancer agents and therapeutic agents for immunologic diseases thereof

6-Amino-9-benzyl-8-hydroxy-purine derivatives and interferon inducers, antiviral agents, anticancer agents and therapeutic agents for immunologic diseases thereof

机译:6-氨基-9-苄基-8-羟基嘌呤衍生物及其干扰素诱导剂,抗病毒药,抗癌药和用于免疫性疾病的治疗剂

摘要

The heterocyclic compound (or salt thereof) has the formula (I): wherein X is S, O, or -NR3- (in which R3 is H, alkyl or substituted alkyl, or may form an optionally substituted heterocyclic ring together with R1 via the nitrogen atom); R1 is optionally substituted alkyl, optionally substituted aryl, or optionally substituted heterocyclic; and R2 is H, or one or more substituents on the benzene ring independently selected from hydroxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkanoyl, optionally substituted aroyl, carboxyl, optionally substituted lower alkoxycarbonyl, amino, lower alkylamino, di(lower alkyl)amino, carbamoyl, lower alkylcarbamoyl, di(lower alkyl)carbamoyl, halogen, nitro or cyano. Also described is a pharmaceutical composition comprising the compound of formula (I) or its pharmaceutically acceptable salt. Also described are interferon inducers, antiviral agents, anticancer agents and therapeutic agents for immunologic diseases; which comprise the compound of formula (I) or its pharmaceutically acceptable salt.
机译:杂环化合物(或其盐)具有式(I):其中X为S,O或-NR 3-(其中R 3为H,烷基或取代的烷基,或可以与R 1一起形成任选取代的杂环。氮原子); R1是任选取代的烷基,任选取代的芳基或任选取代的杂环; R2为H,或苯环上的一个或多个取代基,独立地选自羟基,任选取代的低级烷基,任选取代的低级烷氧基,任选取代的低级烷酰基,任选取代的芳酰基,羧基,任选取代的低级烷氧基羰基,氨基,低级烷基氨基,二(低级烷基)氨基,氨基甲酰基,低级烷基氨基甲酰基,二(低级烷基)氨基甲酰基,卤素,硝基或氰基。还描述了包含式(I)化合物或其药学上可接受的盐的药物组合物。还描述了用于免疫疾病的干扰素诱导剂,抗病毒剂,抗癌剂和治疗剂。它们包含式(I)的化合物或其药学上可接受的盐。

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