首页> 外国专利> Pharmaceutical compositions containing N-sulphonyl indoline derivatives and a solubilizing/stabilizing system having either a nonionic hydrophilic compound having amphiphilic and surfactant properties or a mixture of an amphiphilic compound and a nonionic hydrophilic surfactant

Pharmaceutical compositions containing N-sulphonyl indoline derivatives and a solubilizing/stabilizing system having either a nonionic hydrophilic compound having amphiphilic and surfactant properties or a mixture of an amphiphilic compound and a nonionic hydrophilic surfactant

机译：含有N-磺酰基二氢吲哚衍生物和增溶剂/稳定体系的药物组合物，该体系具有具有两亲和表面活性剂性质的非离子亲水化合物或两亲化合物与非离子亲水表面活性剂的混合物

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摘要

A process for preparing a pharmaceutical composition which is microemulsifiable or emulsifiable in an aqueous medium comprising dissolving a hydrophobic derivative of N-sulphonylindoline of formula (I) in a solubilizing/stabilizing system comprising one or more constituents selected from amphiphilic compounds, nonionic hydrophilic surfactant and nonionic hydrophilic compounds endowed with both amphiphilic and surfactant properties. The system comprises at least one mixture of an amphiphilic compound and a nonionic hydrophilic surfactant or at least one nonionic hydrophilic compound endowed with both amphiphilic and surfactant properties. A pharmaceutical composition which is microemulsifiable or emulsifiable in an aqueous medium containing a hydrophobic derivative of N-sulphonylindoline of formula (I) in a solubilizing/stabilizing system as defined above optionally with an appropriate pharmaceutical excipient or vehicle is also disclosed.

机译：一种制备在水性介质中可微乳化或乳化的药物组合物的方法，该方法包括将式（I）的N-磺基吲哚啉的疏水性衍生物溶解在增溶/稳定体系中，该增溶/稳定体系包含一种或多种选自两亲化合物，非离子亲水性表面活性剂和具有两亲和表面活性剂性质的非离子亲水化合物。该系统包括两亲化合物和非离子亲水性表面活性剂的至少一种混合物或至少一种具有两亲和表面活性剂性质的非离子亲水性化合物。还公开了一种药物组合物，其在如上所定义的增溶/稳定化体系中任选地与合适的药物赋形剂或赋形剂一起在包含式（I）的N-磺酰吲哚啉的疏水性衍生物的水性介质中微乳化或乳化。

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公开/公告号NZ335750A

专利类型
公开/公告日2001-06-29

原文格式PDF
申请/专利权人 SANOFI-SYNTHELABO;
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申请/专利号NZ19970335750
发明设计人 GAUTIER JEAN-CLAUDE;FULLER SIMON JOHN;
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申请日1997-12-04
分类号A61K31/40;A61K9/107;A61K9/48;A61K47/30;
国家 NZ
入库时间 2022-08-22 01:24:18

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