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Meso-monoiodo-substituted tetramacrocyclic compounds and methods for making and using the same
Meso-monoiodo-substituted tetramacrocyclic compounds and methods for making and using the same
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机译：中-单碘取代的四大环化合物及其制备和使用方法
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摘要
A meso-monoiodo-substituted tetramacrocyclic compound having the formula (I): IMAGE (I) wherein: each of A through D is independently a 5-membered, nitrogen-containing ring having the members necessary to complete a porphyrin, chlorin, bacteriochlorin or isobacteriochlorin nucleus; R1 through R8 are independently a hydrogen atom, a lower alkyl group, a lower alkyl carboxylic acid or acid ester group, keto, hydroxy, nitro, amino, or a group that, taken together with another ring, ring substituent or meso-substituent, forms a fused 5- or 6-membered ring; and each of S1 through S3 is H, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, a substituted or unsubstituted aromatic ring, or a substituted or unsubstituted heterocyclic ring. A method for synthesizing the compound comprises the step of iodinating a corresponding unhalogenated, de-metallated tetramacrocyclic compound, followed by metallating. The compound of the invention is an intermediate capable of coupling with an alkyne to achieve a desired mono-meso-alkynyl compound.
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机译：具有式（I）的内-单碘取代的四大环化合物：其中，A至D各自独立地为具有完成卟啉，二氢卟酚所必需的成员的5元含氮环，细菌素或异细菌素核; R 1至R 8独立地是氢原子，低级烷基，低级烷基羧酸或酸酯基，酮基，羟基，硝基，氨基或与另一个环，环取代基或内消旋取代基一起的基团，形成稠合的5元或6元环; S1至S3分别为H，取代或未取代的烷基，取代或未取代的环烷基，取代或未取代的芳环或取代或未取代的杂环。合成该化合物的方法包括以下步骤：碘化相应的未卤代，去金属化的四大环化合物，然后进行金属化。本发明的化合物是能够与炔烃偶联以获得所需的单-间-炔基化合物的中间体。
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