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PROCESS FOR MANUFACTURING TOPICAL OPHTHALMIC PREPARATIONS WITHOUT SYSTEMIC EFFECTS

机译:在没有系统影响的情况下进行常规眼科手术的制备过程

摘要

For treating eye diseases, various kinds of medications are used. They are used in form of topical preparations or in form of systemic preparations to be taken orally or parenterally. Of topical preparations some are for topical use only e.g. framycetin, neomycin, loteprednol ebanoate, etc. However, large majority of topical ophthalmic drugs are for systemic use also, e.g.. Ciprofloxacin, Gentamicin, Timolol, Clonidine, Dexamethasone, Betamethasone, Carbachol, etc. Some of these drugs when used topically are also found to have systemic effects and if they are of serious nature limits the use of that drug, e.g. cardiopulmonary effects of B-blockers like timolol. Dryness of mouth, flush, fever, tachy cardia, urinary retention, convulsion irritability with atropine. Hypertension with phenylephine. Increased salivation, nausea, vomiting, diarrhea, stomach cramps, bronchial secretions, bronchial constriction, asthma, bradycardia, paresthesia with miotics, Hypotension with clonidine. Dry mouth, fatigue and drowsiness with apraclonidine and brimonidine.
机译:为了治疗眼疾,使用了各种药物。它们以局部制剂的形式或全身性制剂的形式使用,以口服或胃肠外给药。在局部制剂中,一些仅用于局部使用,例如。 framycetin,neomycin,ebeprednol ebanoate等。但是,大多数局部眼科药物也可全身使用,例如环丙沙星,庆大霉素,蒂莫洛尔,可乐定,地塞米松,倍他米松,卡巴胆碱等。其中一些局部使用的药物也被发现具有全身作用,如果性质严重,则限制该药的使用,例如B阻滞剂(如噻吗洛尔)的心肺作用。口干,潮红,发烧,心动过速,尿retention留,阿托品对惊厥易怒。与苯肾上腺素的高血压。唾液增加,恶心,呕吐,腹泻,胃痉挛,支气管分泌物,支气管收缩,哮喘,心动过缓,感觉异常者(含表情符号),低血压伴可乐定。 apraclonidine和溴莫尼定可引起口干,疲劳和嗜睡。

著录项

  • 公开/公告号IL138824D0

    专利类型

  • 公开/公告日2001-10-31

    原文格式PDF

  • 申请/专利权人 BAKULESH MAFATLAL KHAMAR;

    申请/专利号IL20000138824

  • 发明设计人

    申请日2000-02-02

  • 分类号7A61KA;

  • 国家 IL

  • 入库时间 2022-08-22 01:24:46

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