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METHOD FOR ENHANCING THE IMMUNOTHERAPEUTIC ACTIVITY OF LYMPHOCYTES TO DECREASE THE TUMOR BURDEN BY STIMULATION OF LYMPHOCYTES IN VITRO IN THE PRESENCE OF ANTI-CD3-ANTIBODY AND BY CO-ADMINISTRATION OF IL-2, KITS CONTAINING SUCH ENHANCED LYMPHOCYTES AND THEIR USE IN PREPARATION OF A MEDICAMENT FOR CANCER THERAPY
METHOD FOR ENHANCING THE IMMUNOTHERAPEUTIC ACTIVITY OF LYMPHOCYTES TO DECREASE THE TUMOR BURDEN BY STIMULATION OF LYMPHOCYTES IN VITRO IN THE PRESENCE OF ANTI-CD3-ANTIBODY AND BY CO-ADMINISTRATION OF IL-2, KITS CONTAINING SUCH ENHANCED LYMPHOCYTES AND THEIR USE IN PREPARATION OF A MEDICAMENT FOR CANCER THERAPY
The present invention is directed to a method of increasing the in vivo immune response of lymphocytes by stimulating the lymphocytes in vitro in the presence of an anti-CD3 monoclonal antibody for less than about 24 hours to form stimulated lymphocytes; infusing the stimulated lymphocytes into a tumor-bearing mammal; and administering IL-2 to the mammal. As a result of this method, the anti-CD3 stimulated lymphocytes display enhanced immunotherapeutic, e.g., cytotoxicity or lymphokine production, in vivo as represented by a decrease in the number of tumors by at least about 20%.
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