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首页> 外国专利> Proteu00ecnas seaweeds as analgesic activity analgesic drugs: the lectinas algae bryothamnion seaforthii (Turner) Kutz (BS - LEC) and bryothamnion triquetrum (s.g.gmel) M.Howe (BT - LEC)

Proteu00ecnas seaweeds as analgesic activity analgesic drugs: the lectinas algae bryothamnion seaforthii (Turner) Kutz (BS - LEC) and bryothamnion triquetrum (s.g.gmel) M.Howe (BT - LEC)

机译：Prote u00ecnas海藻作为止痛活性止痛药：洋紫苏藻（brinthamnion seaforthii（Turner）Kutz（BS-LEC）和bryothamnion triquetrum（s.g.gmel）M.Howe（BT-LEC）

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b "proteu00ecnas seaweeds as analgesic activity analgesic drugs: the lectinas algae bryothamnion seaforthii d (Turner) Kutz b (BS - LEC) d and b bryothamnion triquetrum d (S.G.Gmel) M. Howe b (BT - LEC) '' d . The novelty of this work is linked mainly to the discovery of important lectinas analgesic activities of two marine algae, b.seaforthii and B.Triquetrum.Both lectinas b (BS - LEC and bt - LEC) d , were obtained from aqueous extracts of fresh seaweed in study through a sequence of events involving acidification of the extracts.Salt precipitation and ion exchange chromatography on DEAE cellulose.The lectinas, thus obtained correspond to the only copies included in this class of proteins.With proven analgesic activity (as literature review particular or search alone, recent, requested the INPI).The news comes, therefore, the discovery of two drugs, caracrterizadas for its activities antinociceptivas, peripheral and central action.As biotechnology tools, such lectinas represent a new molecular model for drugs with analgesic activity.With the use of practices possible genetic engineering, would open the way for the isolation and cloning of genes coding for these proteins, and in this way.These drugs could be produced in large quantities and at a low cost. New formulations were prepared and used as a potent analgesics.Additional studies, structural and pharmacological tests are being performed for a better understanding of the events related to the activities of lectinas.
机译：海藻作为镇痛活性镇痛药：菜豆藻bryothamnion seaforthii （Turner）Kutz （BS-LEC）和 bryothamnion triquetrum （SGGmel ）M. Howe （BT-LEC）” 。这项工作的新颖性主要与发现两种海藻b.seaforthii和B.Triquetrum的重要的lectinas镇痛作用有关。 b>（BS-LEC和bt-LEC）是从研究中的新鲜海藻水提取物中经过一系列涉及提取物酸化的事件得到的。盐沉淀和DEAE纤维素上的离子交换色谱法。止痛药具有经证实的止痛活性（如文献综述或单独检索，近期需要INPI），因此有消息发现了两种药物，即caracrterizadas，其具有镇痛作用。 ，周围和中央作用。作为生物技术这些凝集素代表了具有镇痛活性的药物的新分子模型，通过实践的可能的遗传工程，将为分离和克隆编码这些蛋白质的基因开辟道路，并以此方式。以低成本大量生产。制备了新的制剂并将其用作有效的镇痛药。正在进行其他研究，结构和药理试验，以更好地了解与凝集素活性有关的事件。

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