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Low the degree of substitution hydroxypropyl cellulose, it is low the degree of substitution hydroxypropyl cellulose collapse medicine and its production method
Low the degree of substitution hydroxypropyl cellulose, it is low the degree of substitution hydroxypropyl cellulose collapse medicine and its production method
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机译：低取代度羟丙基纤维素，低取代度羟丙基纤维素塌陷药及其生产方法
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摘要
PROBLEM TO BE SOLVED: To obtain the subject compound capable of providing excellent collapsibility to a tablet and a granule even in addition of a small amount by specifying a proportion of one-substituted body in anhydrous glucose units in a cellulose substituted with a hydroxypropyl group. ;SOLUTION: The objective compound is obtained by regulating the proportion of one-substituted body having only one molecule substituted with a hydroxypropyl group in anhydrous glucose units substituted with the hydroxypropyl groups so as to be ≥80mol% of the whole glucose units containing plural number-substituted body. The compound is obtained by reacting (i) a pulp containing ≤0.07wt.%, preferably 0.05wt.% dichloromethane-soluble portion with (ii) (A) an alkali cellulose obtained by impregnation of sodium hydroxide and (B) 0.2-1.0mol propylene oxide per anhydrous glucose unit of the component A at 40-80°C for 1-5hr, neutralizing the free alkali in the reaction product with an acid, and washing, drying and pulverizing the neutralized reaction product.;COPYRIGHT: (C)1998,JPO
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