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Antibodies which bind granulocyte-macrophane colony-stimulating factor receptor

机译:结合粒细胞-巨养集落刺激因子受体的抗体

摘要

The invention provides a recombinant or synthetic receptor or a derivative thereof, for granulocyte-macrophage colony-stimulating factor (GM-CSF). The GM-CSF receptor is useful, inter alia, in the treatment or diagnosis of GM-CSF-related diseases, and in the screening of agonists and antagonists of GM-CSF receptors. The invention further provides antibodies directed against GM-CSF receptor or derivatives thereof, and pharmaceutical compositions comprising either the GM-CSF receptor, the receptor derivative, or an antibody thereto, and methods of using thereof.
机译:本发明提供了一种用于粒细胞-巨噬细胞集落刺激因子(GM-CSF)的重组或合成受体或其衍生物。 GM-CSF受体尤其可用于治疗或诊断与GM-CSF有关的疾病,以及用于筛选GM-CSF受体的激动剂和拮抗剂。本发明进一步提供了针对GM-CSF受体或其衍生物的抗体,以及包含GM-CSF受体,受体衍生物或其抗体的药物组合物,及其使用方法。

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