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Anti-idiotypic monoclonal antibodies and compositions including the anti- idiotypic monoclonal antibodies

机译：抗独特型单克隆抗体和包括抗独特型单克隆抗体的组合物

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摘要

An anti-idiotypic monoclonal antibody that is specific against the N- glycolyl residues of gangliosides, particularly those expressed by cancer cells. The monoclonal antibody is useful as an immunomodulator for cancer treatment. Specifically, the anti-idiotype monoclonal antibody of the present invention is capable of inducing a predominant anti-idiotypic response in xenogeneic models. The anti-idiotypic monoclonal antibody also exerts a protective effect against malignant tumors in animals.

机译：一种抗独特型单克隆抗体，对神经节苷脂（尤其是癌细胞表达的神经节苷脂）的N-乙醇酰基残基具有特异性。单克隆抗体可用作癌症治疗的免疫调节剂。具体地，本发明的抗独特型单克隆抗体能够在异种模型中诱导主要的抗独特型应答。抗独特型单克隆抗体还对动物的恶性肿瘤发挥保护作用。

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公开/公告号US6063379A

专利类型
公开/公告日2000-05-16

原文格式PDF
申请/专利权人 CENTRO DE INMUNOLOGIA MOLECULAR;
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申请/专利号US19980015540
发明设计人 ANA MARIA VAZGUEZ LOPEZ;ROLANDO PEREZ RODRIGUEZ;ELADIO IGLESIS GUERRA;ALEXIS PEREZ;GUMERSINDA BOMBINO LOPEZ;IRENE BEAUSOLEIL DELGADO;
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申请日1998-01-29
分类号A61K39/395;C07K16/00;
国家 US
入库时间 2022-08-22 01:37:10

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