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Cloned tetrodotoxin-sensitive sodium channel -subunit and a splice variant thereof

机译:河豚毒素敏感性克隆的钠通道亚基及其剪接变体

摘要

DNA encoding for a voltage-gated, TTX-sensitive sodium channel is isolated. Also disclosed are polypeptide products of recombinant expression of these DNA sequences, expression vectors comprising the DNA sequences, and host cells transformed with these expression vectors. Other aspects of this invention are peptides whose sequences are based on the amino acid sequences deduced from these DNA sequences, antibodies specific for such proteins and peptides, procedures for detection and quantitation of such proteins, and nucleic acids related thereto. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin- sensitive sodium channel as a therapeutic target for compounds.
机译:分离出编码电压门控,TTX敏感的钠通道的DNA。还公开了这些DNA序列的重组表达的多肽产物,包含该DNA序列的表达载体和用这些表达载体转化的宿主细胞。本发明的其他方面是其序列基于从这些DNA序列推导的氨基酸序列的肽,对此类蛋白质和肽具有特异性的抗体,用于检测和定量此类蛋白质的程序以及与之相关的核酸。本发明的另一方面是该电压门控的河豚毒素敏感性钠通道作为化合物的治疗靶标的用途。

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