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New peptide derived from the MUC-1 tumor marker, used to induce a cytotoxic T cell response for treatment or prevention of tumors
New peptide derived from the MUC-1 tumor marker, used to induce a cytotoxic T cell response for treatment or prevention of tumors
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机译：衍生自MUC-1肿瘤标志物的新肽，用于诱导细胞毒性T细胞应答以治疗或预防肿瘤
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摘要
Peptide (I) derived from the MUC-1 gene and able to induce an HLA (human leukocyte antigen)-A2-restricted immune reaction against tumor cells, is new. (I) has a 10 amino acid sequence (S1) fully defined in the specification, a sequence derived from the MUC-1 signal peptide, especially a 9 amino acid sequence (S2) fully defined in the specification, and/or modified forms of both. (I) has the formula (S1) and/or (S2). Ser-Thr-Thr-Ala-Pro-Pro-Val-His-Asn-Val (S1) Leu-Leu-Leu-Leu-Thr-Val-Leu-Thr-Leu (S2) Independent claims are also included for the following: (1) a nucleic acid (II) comprising a sequence that encodes (I); and (2) a pharmaceutical composition containing (I) and/or (II) in an amount sufficient to induce an MHC (major histocompatibility complex)-1 restricted immune response.
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