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Diagnosing sepsis and severe infections, useful for assessing severity and progress of treatment, by measuring content of peptide prohormone or their derived fragments
Diagnosing sepsis and severe infections, useful for assessing severity and progress of treatment, by measuring content of peptide prohormone or their derived fragments
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机译：诊断败血症和严重感染，可通过测量肽原激素或其衍生片段的含量来评估严重程度和治疗进展
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摘要
A method (I) for the differential diagnosis for early recognition of sepsis or severe infections, particularly sepsis-like systemic infections, is new. A method (I) for the differential diagnosis for early recognition of sepsis or severe infections, particularly sepsis-like systemic infections, is new and comprises determining, in a patient sample: (a) the amount of at least one peptide prohormone (II), other than procalcitonin, and/or derived peptides, the presence and/or amount of (II) being correlated with the presence of sepsis or similar infections, its severity and/or the results of treatment; or (b) the amount of dipeptidyl-peptidase IV (III) in a serum or plasma sample, with a significantly reduced level being indicative of sepsis or similar infection. Independent claims are also included for the following: (1) procalcitonin 3-116 (IV), produced by gene technology methods; (2) production of (IV); and (3) a method for measuring (IV) as an indication-independent diagnostic parameter.
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