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METHOD OF PREPARING OF OXIDIZED GLUTATHIONE-CIS- DIAMINODICHLOROPLATINUM COMPLEX AND PHARMACEUTICAL COMPOSITIONS BASED ON THIS COMPLEX FOR CONTROLLING METABOLISM, PROLIFERATION, AND DIFFERENTIATION, AND MECHANISMS OF APOPTOSIS OF NORMAL AND TRANSFORMATED CELLS
METHOD OF PREPARING OF OXIDIZED GLUTATHIONE-CIS- DIAMINODICHLOROPLATINUM COMPLEX AND PHARMACEUTICAL COMPOSITIONS BASED ON THIS COMPLEX FOR CONTROLLING METABOLISM, PROLIFERATION, AND DIFFERENTIATION, AND MECHANISMS OF APOPTOSIS OF NORMAL AND TRANSFORMATED CELLS
FIELD: pharmaceutical industry. SUBSTANCE: preparation of biologically-active complex is carried out in single-step oxidation of reduced glutathione wherein cis-diaminodichloroplatinum additive acts as oxidation catalyst. Under these conditions, reaction is suited to be controlled, under-stoichiometric amount of hydrogen peroxide is used, formation of peroxidation products is avoided, and yield of desired product is quantitative. Complex and its chemical modifications are characterized by strengthened disulfide linkage when introduced into biological media, which prolongs preparation half-life in these media. Compositions containing the complex can be used to prepare drugs. EFFECT: increased pharmaceutical value of preparation. 28 cl, 14 dwg, 37 tbl, 17 ex
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