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CAPSULES FOR ORAL PREPARATIONS AND CAPSULE PREPARATIONS FOR ORAL ADMINISTRATION

机译:口服制剂的胶囊和口服给药的制剂

摘要

PURPOSE: Capsules for oral preparations are provided which are useful for colon diseases such as colon cancer, ulcerative colon inflammation, constipation and diarrhea, and systemic diseases such as osteoporosis. CONSTITUTION: The capsules for oral preparations undergo no changes in the stomach and small intestine but, after getting to the large intestine, disintegrate and quickly liberate the drugs encapsulated therein at the same time. These capsules have the base which is made from hydroxypropylmethylcellulose (HPMC)optionally containing polyethylene glycol, gelatin or catching. On the surface of the capsule base in which a powder or liquid containing physiological active substance(s) is encapsulated, there is formed a double-coating structure consisting of the inner layer made from a cationic copolymer and the outer layer made from an anionic copolymer.
机译:目的:提供用于口服制剂的胶囊,其可用于结肠疾病,例如结肠癌,溃疡性结肠炎症,便秘和腹泻,以及全身性疾病,例如骨质疏松症。组成:口服制剂的胶囊在胃和小肠中没有变化,但是到达大肠后,崩解并迅速释放其中所包裹的药物。这些胶囊具有由羟丙基甲基纤维素(HPMC)制成的基质,该基质可任选地包含聚乙二醇,明胶或捕捞剂。在胶囊基质的表面上,其中包封含有生理活性物质的粉末或液体,形成了由阳离子共聚物制成的内层和阴离子共聚物制成的外层组成的双层结构。 。

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