首页>
外国专利>
Animal model for the development and therapy of diabetes mellitus
Animal model for the development and therapy of diabetes mellitus
展开▼
机译:用于糖尿病发展和治疗的动物模型
展开▼
页面导航
摘要
著录项
相似文献
摘要
A recombinant GIP (Glucose dependent insulinotropic / insulin releasing polypeptide) receptor protein (I) or an active fragment of (I), which binds to the GIP peptide hormone without initiating a signal transduction cascade, is new. Independent claims are also included for the following: (1) a recombinant DNA molecule (II), encoding (I) or its active fragment, comprising: (a) a promoter that is in the beta cells of the pancreas; (b) a sequence that is capable of binding to the GIP peptide hormone without initiating a signal transduction cascade; (c) a termination sequence; and (d) a polyadenylated tail sequence, where the expression of (II) in a suitable host causes a diabetes type phenotype. (2) a vector (III), comprising (II); (3) a eukaryotic or prokaryotic cell line (IV), containing (II) or (III); (4) a transgenic, non human animal (V), containing (II); and (5) preparing (V).
展开▼