首页> 外国专利> NUCLEIC ACIDS AND PROTEINS OF A RAT GANGLIOSIDE GM1-SPECIFIC αl→2FUCOSYLTRANSFERASE AND USES THEREOF

NUCLEIC ACIDS AND PROTEINS OF A RAT GANGLIOSIDE GM1-SPECIFIC αl→2FUCOSYLTRANSFERASE AND USES THEREOF

机译：大鼠刚柳苷GM1特异性α1→2岩藻糖基转移酶的核酸和蛋白及其用途

页面导航

摘要
著录项
相似文献

摘要

A rat ganglioside GM1-specific α1→2fucosyltransferase is disclosed. Nucleotide sequences of a rat ganglioside GM1-specific α1→2fucosyltransferase, amino acid sequences of its encoded protein (including peptide or polypeptide), and derivatives thereof are described. Also described are fragments (and derivatives and analogs thereof) which comprise a domain of rat ganglioside GM1-specific α1→2fucosyltransferase with catalytic activity. Methods of production of rat ganglioside GM1-specific α1→2fucosyltransferase and derivatives and analogs thereof (e.g. by recombinant means) are provided. Methods of inhibiting the function of rat ganglioside GM1-specific α1→2fucosyltransferase (e.g. by means of antisense RNA) are provided. Methods of commercial scale use of the rat ganglioside GM1-specific α1→2fucosyltransferase in the production of fucosyl-saccharide compositions are described. Applications of these compositions, e.g. as additives for human nutritive compositions or immunotherapeutics for cancer, are disclosed.

机译：公开了大鼠神经节苷脂GM1特异性α1→2岩藻糖基转移酶。描述了大鼠神经节苷脂GM1特异性α1→2岩藻糖基转移酶的核苷酸序列，其编码的蛋白质（包括肽或多肽）的氨基酸序列及其衍生物。还描述了包含具有催化活性的大鼠神经节苷脂GM1特异性α1→2岩藻糖基转移酶的结构域的片段（及其衍生物和类似物）。提供了大鼠神经节苷脂GM1特异性α1→2岩藻糖基转移酶及其衍生物和类似物（例如通过重组手段）的生产方法。提供了抑制大鼠神经节苷脂GM1特异性α1→2岩藻糖基转移酶功能的方法（例如通过反义RNA）。描述了大鼠神经节苷脂GM1特异性α1→2岩藻糖基转移酶在岩藻糖基糖组合物生产中的商业规模使用方法。这些组合物的应用例如公开了作为人类营养组合物的添加剂或用于癌症的免疫疗法的添加剂。

著录项

公开/公告号WO0064464A1

专利类型
公开/公告日2000-11-02

原文格式PDF
申请/专利权人 NORTHWEST HOSPITAL;
展开▼

申请/专利号WO1999US07384
发明设计人 HOLMES ERIC H.;SHERWOOD ANNE L.;
展开▼

申请日1999-04-23
分类号A61K38/00;A01N37/18;A01N43/04;A61K38/00;A61K39/00;C07H21/04;C12N5/00;C12N15/00;C12P21/06;C12Q1/68;C12N6/02;
国家 WO
入库时间 2022-08-22 01:49:20

相似文献

专利
外文文献
中文文献