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COMBINATION THERAPY OF CANCER BY THE ACTIVATION OF CO-STIMULATORY MOLECULES EXPRESSED BY IMMUNE CELLS AND CYTOKINES

机译:免疫细胞和细胞因子表达的协同刺激分子的激活对癌症的联合治疗

摘要

The present invention relates to methods and compositions for the treatment, prevention or inhibition of diseases and disorders, including cancer, inflammatory diseases or disorders, and infectious diseases, comprising compounds which augment activated immune cells, i.e., T-cells and natural killer ("NK") cells. In particular, the present invention relates to methods and compositions for the treatment, prevention or inhibition of diseases and disorders, including cancer, inflammatory diseases or disorders, and infectious diseases, comprising the administration of a compound that activates one or more cytokine receptors and a compound that activates one or more co-stimulatory molecules expressed by activated immune cells, i.e., activated T-cells.
机译:本发明涉及用于治疗,预防或抑制疾病和病症的方法和组合物,所述疾病和病症包括癌症,炎性疾病或病症和传染性疾病,其包含增强活化的免疫细胞,即T细胞和天然杀伤剂的化合物(“ NK“)细胞。特别地,本发明涉及用于治疗,预防或抑制疾病和病症的方法和组合物,所述疾病和病症包括癌症,炎性疾病或病症以及感染性疾病,包括给予激活一种或多种细胞因子受体的化合物和药物。激活一种或多种由激活的免疫细胞(即激活的T细胞)表达的共刺激分子的化合物。

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