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Radiation and nanoparticles for enhancement of drug delivery in solid tumors

机译：辐射和纳米粒子可增强实体瘤中的药物输送

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摘要

The present invention discloses a method/system utilizing interaction of electromagnetic pulses or ultrasonic radiation with nano- and microparticles for enhancement of drug delivery in solid tumors. The particles can be attached to antibodies directed against antigens in tumor vasculature and selectively delivered to tumor blood vessel walls. Cavitation induced by ultrasonic waves or local heating of the particles by pulsed electromagnetic radiation results in perforation of tumor blood vessels, microconvection in the interstitium, and perforation of cancer cell membrane, and therefore, provides enhanced delivery of macromolecular therapeutic agents from blood into cancer cells with minimal thermal and mechanical damage to normal tissues.

机译：本发明公开了一种利用电磁脉冲或超声辐射与纳米和微粒的相互作用来增强实体瘤中药物递送的方法/系统。所述颗粒可以附着于针对肿瘤脉管系统中的抗原的抗体，并选择性地递送至肿瘤血管壁。超声波引起的空化或脉冲电磁辐射对颗粒的局部加热导致肿瘤血管的穿孔，间质中的微对流以及癌细胞膜的穿孔，因此，可增强大分子治疗剂从血液到癌细胞的输送对正常组织的热损伤和机械损伤最小。

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公开/公告号AU4854599A

专利类型
公开/公告日2000-02-01

原文格式PDF
申请/专利权人 BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM THE;
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申请/专利号AU19990048545
发明设计人 RINAT O. ESENALIEV;
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申请日1999-07-01
分类号A61K48/00;A61K39/395;A61K38/19;C07H21/04;C07H21/02;
国家 AU
入库时间 2022-08-22 01:51:36

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