首页>
外国专利>
Farmasøytiske preparater for mÕlrettet erstatning av østrogenmangel i sentralnervesystemet
Farmasøytiske preparater for mÕlrettet erstatning av østrogenmangel i sentralnervesystemet
展开▼
机译：靶向治疗中枢神经系统雌激素缺乏症的药物制剂
展开▼
页面导航
摘要
著录项
相似文献
摘要
Selected steroids are used to produce pharmaceutical preparations for selectively supplementing oestrogen deficiency in the central nervous system (CNS) without influencing other organs or systems. These steroids are characterised in that they have a selective, neurotropic, oestrogen-like transcription effect, unlike the systemically active natural and synthetic oestrogens, including 17a-estradiol. It has been surprisingly discovered that the selected steroids, when used according to the invention, selectively influence the transcription of oestrogen-dependent genes in the central nervous system and cause alterations of the corresponding physiological parameters; have transcription effects specific to the central nervous systems in doses which have no biological effects on the tissues of the reproductive system; have transcription effects specific to the central nervous system at doses at which neither 17b-estradiol nor 17a-estradiol have any effect; and do not influence the transcription of oestrogen-dependent genes in the central nervous system to a greater extent than the secondary 17b-estradiol.
展开▼
