首页> 外国专利> Preparation method of acilaromaticos through acylation of an Aromatic Compound with an Acid carboxilicoen presence of acid and a strong acid polifosforico protico and ProcedurePreparation for acilfenoxietilamina - including acylation, useful as intermediaries.

Preparation method of acilaromaticos through acylation of an Aromatic Compound with an Acid carboxilicoen presence of acid and a strong acid polifosforico protico and ProcedurePreparation for acilfenoxietilamina - including acylation, useful as intermediaries.

机译：通过将芳香族化合物与酸，羧酸和强酸多聚磷酰质子酸存在下的芳族化合物进行酰化的制备方法，以及包括中间体在内的酰化草胺酰胺的制备方法。

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摘要

This Invention provides a process for preparing acilaromaticos,Comprising reacting an Aromatic Compound with an Acid carbolxilico presence of a reaction Medium that includes polifosforico acid and a strong acid protico.In One embodiment, The Invention provides a process for preparing a fenoxietilamina for acyl,Comprising the steps of reacting a compound 2 - fenoxiletilo porta a leaving Group at position 1 of Ethyl with a carboxylic acid in the presence of immunological ReactionThat includes polifosforico acid and a strong acid protico,To form an intermediate acyl fenoxietilo Carrying the leaving Group; and the recacionar Intermediate acyl fenoxietilo with an Amine Group to replace the outgoing PAra to form Acyl fenoxietilamina.

机译：本发明提供了一种制备环己酰胺的方法，该方法包括使芳族化合物与酸羰基西林存在反应的反应介质存在，所述反应介质包括多聚福考酸和强酸质子蛋白。在免疫反应存在下，使包括2-草酸磷酯和强酸质子基团在内的2-乙基非诺西蒂洛门化合物与羧酸发生反应的步骤，形成中间体酰基非诺西蒂罗，携带该离去基团;以及带有胺基团的中间体中间体酰基芬诺昔罗，以取代即将离去的PAra形成酰基苯并噻草胺。

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公开/公告号CL1999002641A1

专利类型
公开/公告日2000-09-27

原文格式PDF
申请/专利权人 CATALYTICA PHARMACEUTICALS INC.;
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申请/专利号CL1999002641
发明设计人 JOHN MYRON GRUBER;ROBERT SEEMAYER;
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申请日1999-11-15
分类号C07C213/02;C07C217/18;C07C303/30;C07C309/66;C07C45/46;C07C49/67;C07C49/782;C07C49/84;C07D307/80;
国家 CL
入库时间 2022-08-22 01:56:59

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